Spinal-fluid protein determination for the differentiation of neurologic disorders.

A simplechemical test previouslydescribedfor the determination of total protein and y-globulin was applied to the analysisof spinal fluid specimens (CSF) from nonneurologic and a variety of neurologic disorders. On the basis of the chemical findings, the pathologic specimens analyzed were divided into three groups: (a) nonneurologic and some neurologic conditions with a normal CSF total protein and yglobulinconcentration; (b) demyelinating disorderswith a normal total protein and elevated .y-globulin concentration; and (c) degenerative and infectious with an elevated total protein and y-globulin. A goodcorrelation between chemical findings and clinical observationwas obtained.